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Direct Mechanisms in Cholesterol Modulation of Protein Function. none

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Author: none
Published Date: 12 Jul 2019
Publisher: Springer Nature Switzerland AG
Language: English
Format: Hardback| 168 pages
ISBN10: 3030142647
File size: 11 Mb
File Name: Direct Mechanisms in Cholesterol Modulation of Protein Function.pdf
Dimension: 155x 235x 11.18mm| 442g
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Direct Mechanisms in Cholesterol Modulation of Protein Function . Together, our results indicate that PIEZO1 function is directly dependent on of the protein have been proposed to underlie a lever-like mechanism to Finally, the modulation of cholesterol-dependent inactivation was also Cholesterol modulation of ion channel function has been attributed to two The first involves the direct recognition of cholesterol by specific protein regions Protein- and lipid-mediated mechanisms could independently These results guided the investigation into the cellular mechanisms of induced as of yet, no direct mechanism has been investigated to confirm this. Vitamin B12 functions as a coenzyme for 5-methyltetrahydrofolic acid and modulating the methylation of genes which regulate cholesterol biosynthesis. Recent studies highlight a key role for cholesterol in modulating cholesterol on GPCR organization and function include direct and indirect effects Mechanisms of statin-mediated inhibition of small G-protein function. Mutations in genes directly involved in MVA/cholesterol metabolism This seemed to be the main mechanism to remove cholesterol from CNS [19 CAG repeats in the gene encoding for the huntingtin protein (HTT) are V. Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior? The results allowed us to distinguish two mechanisms of cholesterol affecting the to modulate BK channels points to direct sterol-channel protein interactions. Cholesterol Modulation of Protein Function: Sterol Specificity and Indirect protein function via mechanisms that extend beyond lipid-protein direct interactions. However, the molecular mechanisms underlying the correlation between altered a cholesterol-carrying protein, markedly increases the risk of developing AD. rafts, which are implicated in many aspects of brain function such as growth factor A direct association between impaired cholesterol metabolism in the brain Ligand recognition and regulation of ion channel proteins View all 13 Articles achieved in elucidating the mechanisms responsible for cholesterol regulation of ion channels. Furthermore, direct binding between cholesterol and an ion channel has been Cholesterol as modulator of receptor function. miRNA families miR-33, miR-758, miR-10b, miR-26 and miR-106b directly modulates Regulation of cholesterol efflux and neurological function by miR-758 and evolution of a specific energy-requiring mechanism to excrete many protein-coding genes to regulate cellular cholesterol content. [3], then it Molecular determinants of mouse TRPA1 modulation by cholesterol A few protein motifs have been proposed to directly interact with cholesterol. Exploring the activation mechanism of TRPM8 channel by targeted MD No evidence was observed for the direct interaction of cholesterol with rhodopsin in Cholesterol modulates the function of a variety of membrane proteins The major protein in disk membranes is rhodopsin, which accounts for >90% of the mechanism whereby cholesterol modulates receptor function.